ODCs

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1 OMIM reference -
1 associated gene
No signs/symptoms info

PROTEIN INTERACTIONS: 1

6 OMIM references -
6 associated genes
24 signs/symptoms

Autosomal dominant limb-girdle muscular dystrophy type 1B

Lamellar ichthyosis


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	LMNA	(0.67)	ALOX12B

Citations in the biomedical literature:

Autosomal dominant limb-girdle muscular dystrophy type 1B		Lamellar ichthyosis
	Synonym(s): - LGMD1B - Limb-girdle muscular dystrophy due to lamin A/C deficiency		Synonym(s): - Classic lamellar ichthyosis - Congenital lamellar ichthyosis - LI

	Classification (Orphanet): - Rare cardiac disease - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare eye disease - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - No MeSH references		External references: 6 OMIM references - 1 MeSH reference: D017490

Lamellar ichthyosis
	Very frequent - Absent / decreased / thin eyebrows - Autosomal recessive inheritance - Decreased body hair / axillar / pubic hairlessness - Dry / squaly skin / exfoliation - Ectropion / entropion / eyelid eversion - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness - Ichthyosis / ichthyosiform dermatitis - Nails anomalies - Pruritus / itching - Tight skin / lack of elasticity Frequent - Everted lower lip - Helix / crux helix absent / abnormal / adherent / crux cymbae / posterior helix pits Occasional - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Chronic / relapsing otitis - Dehydration / hydroelectrolytic loss - Gangrena / necrosis - Intellectual deficit / mental / psychomotor retardation / learning disability - Musculo-tendinous retractions - Renal failure - Repeat respiratory infections - Sepsis severe / septicemia - Short stature / dwarfism / nanism
Autosomal dominant limb-girdle muscular dystrophy type 1B
(no data available)